Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity

@article{AbdelMotal2009IntratumoralIO,
  title={Intratumoral injection of α-gal glycolipids induces a protective anti-tumor T cell response which overcomes Treg activity},
  author={Ussama M Abdel-Motal and Kim Wigglesworth and Uri Galili},
  journal={Cancer Immunology, Immunotherapy},
  year={2009},
  volume={58},
  pages={1545-1556}
}
Abstractα-Gal glycolipids capable of converting tumors into endogenous vaccines, have α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R) and are extracted from rabbit RBC membranes. α-Gal epitopes bind anti-Gal, the most abundant natural antibody in humans constituting 1% of immunoglobulins. α-Gal glycolipids insert into tumor cell membranes, bind anti-Gal and activate complement. The complement cleavage peptides C5a and C3a recruit inflammatory cells and APC into the treated lesion. Anti-Gal further… CONTINUE READING

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