Intratumoral heterogeneity of malignant gliomas measured in vitro.

  title={Intratumoral heterogeneity of malignant gliomas measured in vitro.},
  author={Ayman Allam and Alphonse G. Taghian and D. Gioioso and Margaret Duffy and Herman D. Suit},
  journal={International journal of radiation oncology, biology, physics},
  volume={27 2},
PURPOSE To evaluate the extent of intratumoral heterogeneity of radiation sensitivity in malignant gliomas, by comparing the intrinsic radiation sensitivity of different glioma sublines derived from the same tumor. METHODS AND MATERIALS The study was performed on five early established malignant gliomas (passage 3-10). Each specimen was quickly cut into three equal pieces (except for one specimen, where only two pieces were obtained). Each piece was processed independently, disintegrated into… CONTINUE READING


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