Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals

@article{Costa2015IntratumoralHO,
  title={Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals},
  author={Erico Tosoni Costa and Gabriela Filoso Barnab{\'e} and Mengyang Li and Ana M{\'o}nica Dias and Thalita R M Machado and P. Asprino and Fel{\'i}cia P Cavalher and Elisa Napolitano e Ferreira and Mar{\'i}a del Mar Inda and Ma{\'i}ra H Nagai and Bettina Malnic and Mariana Lemos Duarte and K{\'a}tia Ramos Moura Leite and Alfredo Carlos Sim{\~o}es Dornellas de Barros and Dirce Maria Carraro and Roger Chammas and Hugo Aguirre Armelin and Webster K Cavenee and Frank B Furnari and Anamaria A. Camargo},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={1270-1279}
}
Intratumoral heterogeneity (ITH) represents an obstacle for cancer diagnosis and treatment, but little is known about its functional role in cancer progression. The A Desintegrin And Metalloproteinase 23 (ADAM23) gene is epigenetically silenced in different types of tumors, and silencing is often associated with advanced disease and metastasis. Here, we show that invasive breast tumors exhibit significant ADAM23-ITH and that this heterogeneity is critical for tumor growth and metastasis. We… CONTINUE READING
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