Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma.

@article{Niikawa2008IntratumoralEA,
  title={Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma.},
  author={Hiromichi Niikawa and Takashi Suzuki and Yasuhiro Miki and Satoshi Suzuki and Shuji Nagasaki and Junichi Akahira and Seijiro Honma and Dean B. Evans and Shin-ichi Hayashi and Takashi Kondo and Hironobu Sasano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 14},
  pages={4417-26}
}
PURPOSE The possible involvement of gender-dependent factors has been suggested in human non-small cell lung carcinomas (NSCLC), but their precise roles remain largely unclear. Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC. EXPERIMENTAL DESIGN Fifty-nine frozen specimens of NSCLC were available for liquid chromatography/electrospray tandem mass spectrometry to study intratumoral estradiol concentrations. In addition, A549… CONTINUE READING