Intratumoral estrogen disposition in breast cancer.

  title={Intratumoral estrogen disposition in breast cancer.},
  author={Ben P. Haynes and Anne Hege Straume and J{\"u}rgen Geisler and Roger P A'hern and Hildegunn Helle and Ian E. Smith and Per Eystein L\onning and Mitch Dowsett},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 6},
PURPOSE The concentration of estradiol (E(2)) in breast tumors is significantly higher than that in plasma, particularly in postmenopausal women. The contribution of local E(2) synthesis versus uptake of E(2) from the circulation is controversial. Our aim was to identify possible determinants of intratumoral E(2) levels in breast cancer patients. EXPERIMENTAL DESIGN The expression of genes involved in estrogen synthesis, metabolism, and signaling was measured in 34 matched samples of breast… CONTINUE READING
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