Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography.

@article{Kubota1992IntratumoralDO,
  title={Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography.},
  author={Ryo Kubota and Shogo Yamada and Kazuo Kubota and Kiichi Ishiwata and Nobuaki Tamahashi and Tatsuo Ido},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1992},
  volume={33 11},
  pages={1972-80}
}
While 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is a useful tumor imaging agent, its intratumoral distribution has not been described well at the cellular level. In order to demonstrate cellular localization of [18F]FDG and 2-deoxy-D-[3H]glucose (3H-DG) uptake by the tumor in vivo, C3H/He mice transplanted subcutaneously with FM3A tumors were studied 1 hr after intravenous injection of [18F]FDG or 3H-DG using micro- and macro-autoradiography. Fluorine-18-FDG and 3H-DG showed the same… CONTINUE READING