Intratumoral chemotherapy with a sustained-release drug delivery system inhibits growth of human pancreatic cancer xenografts.

@article{Smith1995IntratumoralCW,
  title={Intratumoral chemotherapy with a sustained-release drug delivery system inhibits growth of human pancreatic cancer xenografts.},
  author={Jill Palmer Smith and Elyse G Stock and Elaine K. Orenberg and Ning Y. Yu and Sarathchandra Kanekal and Dennis M. Brown},
  journal={Anti-cancer drugs},
  year={1995},
  volume={6 6},
  pages={717-26}
}
This study provides the first evidence that treatment of human pancreatic adenocarcinoma is markedly improved by the intratumoral administration of chemotherapeutic agents in a novel drug delivery system. The effect of chemotherapeutic agents delivered in a sustained-release, protein-based, injectable gel was evaluated on the growth of human pancreatic adenocarcinoma cell line, BxPC-3. In vitro chemosensitivity of BxPC-3 cells exposed for 24 or 72 h to fluorouracil (0.01-5 mM), cisplatin or… CONTINUE READING
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