Intratumoral aromatase as a prognostic factor in human breast carcinoma.

  title={Intratumoral aromatase as a prognostic factor in human breast carcinoma.},
  author={Maria D. M. C. Ribeiro da Silva and Martin G. Rowlands and Mark R Dowsett and Barry Gusterson and James McKinna and I. D. Fryatt and R C Coombes},
  journal={Cancer research},
  volume={49 10},
Intratumoral aromatase activity (AA) was measured in 145 samples of human primary breast carcinoma using the tritiated water release assay which quantifies the tritium lost to water during the aromatization of 1 beta-[3H]androstenedione to estrone. Significant AA was detected in 91/145 (63%) tumors. The possibility of a relationship between AA and a variety of clinical prognostic factors such as estrogen receptors, menopausal status, site, size, and histological grade of tumor was investigated… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 26 references

Aroma tase, 17-hydroxysteroid dehydrogenase and intratissular sex hormone con centrations in cancerous and normal glandular breast tissue in postmenopau sal women

A. Vermeulen, R. Deslypere, Leclercq, F Roy, J. C. Heuson
Eur. J. Clin. Oncol., • 1986
View 1 Excerpt

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