Intratumoral and plasma concentrations of gefitinib in breast cancer patients: Preliminary results from a presurgical investigatory study (BCIRG 103).


581 Background: Gefitinib ('Iressa', ZD1839) has a high volume of distribution in animals and humans, with a volume of 1400 L in cancer patients. Consistent with these pharmacokinetic data, gefitinib is extensively distributed into the tissues of rats and mice, with tissue:blood ratios of >10 in a number of organs. Concentrations of gefitinib in mouse… (More)


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