Intratumoral activation of CD8-positive cytotoxic lymphocytes in acquired immunodeficiency syndrome lymphomas.

@article{Devergne1995IntratumoralAO,
  title={Intratumoral activation of CD8-positive cytotoxic lymphocytes in acquired immunodeficiency syndrome lymphomas.},
  author={Odile Devergne and Martine Raphael and Brigitte Autran and Marie-B{\'e}n{\'e}dicte Leger-Ravet and Jean Coumbaras and M C Crevon and Pierre Galanaud and Dominique Emilie},
  journal={Human pathology},
  year={1995},
  volume={26 3},
  pages={284-90}
}
The incidence of lymphomas is unusually high in human immunodeficiency virus (HIV)-infected patients. Because cytotoxic T lymphocytes (CTL) represent a major mechanism of the antitumoral immune response in immunocompetent individuals, we asked whether intratumoral activation of CTL was impaired in acquired immune deficiency syndrome (AIDS) lymphomas. Immunohistochemical experiments showed that in AIDS lymphomas intratumoral CD8-positive T lymphocytes accumulated and expressed the TIA-1 antigen… CONTINUE READING