Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.

@article{Gunnarsson2010IntratumoralID,
  title={Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.},
  author={Salina Gunnarsson and Daniel Bexell and Andreas Svensson and Peter Siesj{\"o} and Anna Darabi and Johan Bengzon},
  journal={Journal of neuroimmunology},
  year={2010},
  volume={218 1-2},
  pages={140-4}
}
The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to… CONTINUE READING