Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.

@article{Fujii2006IntratumorIO,
  title={Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.},
  author={Takuma Fujii and Miyuki Saito and Eri Iwasaki and Takahiro Ochiya and Yoshifumi Takei and Shigenori Hayashi and Akiko Ono and Nobumaru Hirao and Masaru Nakamura and Kaneyuki Kubushiro and Katsumi Tsukazaki and Daisuke Aoki},
  journal={International journal of oncology},
  year={2006},
  volume={29 3},
  pages={541-8}
}
Human papillomavirus (HPV) 18 is related not only to squamous cell carcinoma of the cervix, but also to adenocarcinoma and small cell carcinoma of the cervix, in which prognosis is known to be poor. Small interfering RNA (siRNA) that targets HPV18 E6 and E7 was tested in HPV18-positive cell lines to investigate its effect and investigate its mechanism of action. Nude mice were also tested in a combination of siRNA and atelocollagen to determine whether it might be useful as a new molecule… CONTINUE READING

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