Intratumor heterogeneity in evolutionary models of tumor progression.

  title={Intratumor heterogeneity in evolutionary models of tumor progression.},
  author={Richard Durrett and Jasmine Foo and Kevin Leder and John Mayberry and Franziska Michor},
  volume={188 2},
With rare exceptions, human tumors arise from single cells that have accumulated the necessary number and types of heritable alterations. Each such cell leads to dysregulated growth and eventually the formation of a tumor. Despite their monoclonal origin, at the time of diagnosis most tumors show a striking amount of intratumor heterogeneity in all measurable phenotypes; such heterogeneity has implications for diagnosis, treatment efficacy, and the identification of drug targets. An… CONTINUE READING
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