Intratumor RNA interference of cell cycle genes slows down tumor progression

@article{Dharmapuri2011IntratumorRI,
  title={Intratumor RNA interference of cell cycle genes slows down tumor progression},
  author={S. Dharmapuri and D. Peruzzi and E. Marra and F. Palombo and A. Bett and S. Bartz and M. Yong and G. Ciliberto and N. L. Monica and C. Buser and C. Toniatti and L. Aurisicchio},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={727-733}
}
Small interfering RNAs (siRNAs) are emerging as promising therapeutic tools. However, the widespread clinical application of such molecules as modulators of gene expression is still dependent on several aspects that limit their bioavailability. One of the most promising strategies to overcome the barriers faced by gene silencing molecules involves the use of lipid-based nanoparticles (LNPs) and viral vectors, such as adenoviruses (Ads). The primary obstacle for translating gene silencing… Expand
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