Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

@inproceedings{Deng2013IntratumorHP,
  title={Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer},
  author={Bin Deng and Ji-min Zhu and Yi Wang and Tao-tao Liu and Yanbing Ding and Wei-ming Xiao and Guo-tao Lu and Ping Bo and Xi-Zhong Shen},
  booktitle={PloS one},
  year={2013}
}
Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor immune evasion mechanisms and is a main obstacle for successful tumor immunotherapy. Hypoxia, a common feature of solid tumors, has been associated with potentiated immunosuppression, decreased therapeutic response, malignant progression and local invasion. Unfortunately, the link between hypoxia and Treg-mediated immune tolerance in gastric cancer remains poorly understood. In our study, Tregs and hypoxia… CONTINUE READING
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