Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential

Abstract

Testicular germ cell cancer develops from premalignant intratubular germ cell neoplasia, unclassified cells that are believed to arise from failure of normal maturation of fetal germ cells from gonocytes (OCT4+/MAGEA4−) into pre-spermatogonia (OCT4−/MAGEA4+). Intratubular germ cell neoplasia cell subpopulations based on stage of germ cell differentiation… (More)
DOI: 10.1038/modpathol.2013.246

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