Intratubular crystallization of calcium oxalate in the presence of membrane vesicles: an in vitro study.

@article{Fasano2001IntratubularCO,
  title={Intratubular crystallization of calcium oxalate in the presence of membrane vesicles: an in vitro study.},
  author={J M Fasano and Saeed R. Khan},
  journal={Kidney international},
  year={2001},
  volume={59 1},
  pages={169-78}
}
BACKGROUND Since urine spends only a few minutes in the renal tubules and has a low supersaturation with respect to calcium oxalate (CaOx), nucleation of CaOx crystals in the kidneys is most probably heterogeneous. We have proposed that membranes of cellular degradation products are the main substrate for crystal nucleation. The purpose of our study was to determine the site of membrane-mediated crystal nucleation within the renal tubules and the required lag time, factors that determine… CONTINUE READING

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