Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice

@inproceedings{Kim2011IntratrachealTO,
  title={Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice},
  author={Eun Kim and Yun Sil Chang and Soo Jin Choi and Jin Kyu Kim and Hey Soo Yoo and So Yoon Ahn and Dong Kyung Sung and Soo Yoon Kim and Ye Rim Park and Won Soon Park},
  booktitle={Respiratory research},
  year={2011}
}
BACKGROUND Human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuate hyperoxic neonatal lung injury primarily through anti-inflammatory effects. We hypothesized that intratracheal transplantation of human UCB-derived MSCs could attenuate Escherichia coli (E. coli)-induced acute lung injury (ALI) in mice by suppressing the inflammatory response. METHODS Eight-week-old male ICR mice were randomized to control or ALI groups. ALI was induced by intratracheal E. coli… CONTINUE READING