Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats.

@article{Chang2011IntratrachealTO,
  title={Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats.},
  author={Yun Sil Chang and Soo Jin Choi and Dong Kyung Sung and Soo Yoon Kim and Wonil Oh and Yoon Sun Yang and Won Soon Park},
  journal={Cell transplantation},
  year={2011},
  volume={20 11-12},
  pages={1843-54}
}
Intratracheal transplantation of human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuates the hyperoxia-induced neonatal lung injury. The aim of this preclinical translation study was to optimize the dose of human UCB-derived MSCs in attenuating hyperoxia-induced lung injury in newborn rats. Newborn Sprague-Dawley rats were randomly exposed to hyperoxia (95% oxygen) or normoxia after birth for 14 days. Three different doses of human UCB-derived MSCs, 5 × 10(3) (HT1), 5… CONTINUE READING

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