Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis.

  title={Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis.},
  author={Shawn J. Skerrett and Thomas R. Martin},
  journal={American journal of respiratory and critical care medicine},
  volume={149 1},
To study the effects of recombinant interferon-gamma (IFN-gamma) on pulmonary defenses in vivo, we measured Ia antigen expression by alveolar macrophages and whole-lung clearance of inhaled Legionella pneumophila in normal and corticosteroid-treated rats. We found that Ia antigen was expressed by 7, 29, 50, and 65% of alveolar macrophages harvested from normal rats 24 h after intratracheal administration of 0, 10(3), 10(4), or 10(5) U of IFN-gamma, respectively, and by 76% of alveolar… CONTINUE READING


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