Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.

@article{Panos1995IntratrachealIO,
  title={Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.},
  author={R. Panos and P. M. Bak and W. Simonet and J. Rubin and L. J. Smith},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 4},
  pages={
          2026-33
        }
}
Alveolar type II cell proliferation occurs after many forms of lung injury and is thought to play a critical role in alveolar epithelial repair. Keratinocyte growth factor/fibroblast growth factor 7 (KGF) has been shown to promote alveolar type II cell growth in primary culture and alveolar epithelial hyperplasia in vivo. In this study, we used immunohistochemical analysis to determine the intrapulmonary distribution and cellular localization of recombinant human KGF (rhKGF) instilled into the… Expand
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References

SHOWING 1-10 OF 61 REFERENCES
Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo.
  • 358
Hypertrophic alveolar type II cells from silica-treated rats are committed to DNA synthesis in vitro.
  • 23
Pulmonary fibrosis--a possible mechanism.
  • 198
Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
  • 193
  • PDF
Hyperoxic lung injury in mice: effect of neutrophil depletion and food deprivation.
  • 25
Quantitation of damage to the alveolar epithelium by means of type 2 cell proliferation.
  • 96
...
1
2
3
4
5
...