Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.

@article{Ulich1991IntratrachealIO,
  title={Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.},
  author={Thomas R. Ulich and S R Yin and K. Z. Guo and Eunhee Yi and Daniel G Remick and Juan de Dios Luna del Castillo},
  journal={The American journal of pathology},
  year={1991},
  volume={138 5},
  pages={1097-101}
}
The nature of the endogenous mediators that down-regulate and curtail the exodus of neutrophils into local acute inflammatory sites is unknown. In the present report, interleukin-6 (IL-6) and transforming growth factor beta (TGF beta), members of a family of macrophage-derived proteins known as cytokines, are shown to inhibit significantly the acute neutrophilic exodus caused by an intratracheal injection of endotoxin (LPS), a proinflammatory component of the cell walls of gram-negative… CONTINUE READING

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