Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis.

@article{Tsukui2015IntratrachealCT,
  title={Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis.},
  author={Tatsuya Tsukui and Satoshi Ueha and Shigeyuki Shichino and Yutaka Inagaki and Kouji Matsushima},
  journal={The American journal of pathology},
  year={2015},
  volume={185 11},
  pages={2939-48}
}
Pulmonary fibrosis is a devastating disease for which there are few effective therapies. Activated fibroblasts form subepithelial clusters known as fibroblastic foci, which are characterized by excessive collagen deposition. The origin of activated fibroblasts is controversial and needs to be clarified to understand their pathogenicity. Here, using an intratracheal adoptive cell transfer method, we show that resident fibroblasts in alveolar walls have the highest profibrotic potential. By using… CONTINUE READING
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