Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits.

@article{Imai1999IntratrachealAN,
  title={Intratracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits.},
  author={Yumiko Imai and Toshio Kawano and Sinji Iwamoto and Satoshi Nakagawa and Masao Takata and Katsuyuki Miyasaka},
  journal={Journal of applied physiology},
  year={1999},
  volume={87 2},
  pages={510-5}
}
To evaluate the role of tumor necrosis factor (TNF)-alpha in the pathogenesis of ventilator-induced lung injury, we 1) measured TNF-alpha production in the lung caused by conventional mechanical ventilation (CMV) and 2) evaluated the protective effect of anti-TNF-alpha antibody (Ab) in saline-lavaged rabbit lungs. After they received saline lung lavage, rabbits were intratracheally instilled with 1 mg/kg of polyclonal anti-TNF-alpha Ab in the high-dose group (n = 6), 0.2 mg/kg of anti-TNF-alpha… CONTINUE READING

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