Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.

@article{Helden1997IntratrachealAO,
  title={Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.},
  author={H. V. van Helden and W. C. Kuijpers and D. Steenvoorden and C. Go and P. Bruijnzeel and M. van Eijk and H. Haagsman},
  journal={Experimental lung research},
  year={1997},
  volume={23 4},
  pages={
          297-316
        }
}
The aim of the study was to extend existing evidence that intratracheal aerosolization of LPS may serve as a very relevant model to study ARDS. The authors investigated the sequence of pathogenic events reflected by changes in levels of tumor necrosis factor alpha (TNF alpha), surfactant-associated protein A (SP-A) in BAL fluid, in addition to cell count, edema formation, and respiratory function. Within 24 h following intratracheal aerosolization of LPS in the rat, ARDS could be diagnosed… Expand
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