Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats.

@article{Somanna2014IntratrachealAO,
  title={Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats.},
  author={Naveen K. Somanna and Philipp M. W{\"o}rner and Subramanyam N. Murthy and Edward A. Pankey and Deborah J Sch{\"a}chtele and Rose-Claire St Hilaire and David A.W.A.M. Jansen and Abigail E. Chaffin and Bobby Dean Nossaman and Eckhard U. Alt and Philip J. Kadowitz and Reza Izadpanah},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={307 8},
  pages={
          H1187-95
        }
}
The effect of intratracheal administration of cyclooxygenase-1 (COX-1)-modified adipose stem cells (ASCs) on monocrotaline-induced pulmonary hypertension (MCT-PH) was investigated in the rat. The COX-1 gene was cloned from rat intestinal cells, fused with a hemagglutanin (HA) tag, and cloned into a lentiviral vector. The COX-1 lentiviral vector was shown to enhance COX-1 protein expression and inhibit proliferation of vascular smooth muscle cells without increasing apoptosis. Human ASCs… CONTINUE READING
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