Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse.

@article{Yasui2001IntratrachealAO,
  title={Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse.},
  author={Hisataka Yasui and Esteban C Gabazza and Shigenori Tamaki and Tsutomu Kobayashi and Osamu Hataji and Hisamichi Yuda and Shino Shimizu and Koji A. O. Suzuki and Yukihiko Adachi and Osamu Taguchi},
  journal={American journal of respiratory and critical care medicine},
  year={2001},
  volume={163 7},
  pages={1660-8}
}
It is well recognized that activation of the coagulation system plays an important role in bleomycin (BLM)-induced lung injury and fibrosis. The protein C (PC) pathway is an important regulator of the coagulation system. In this study, we evaluated the bronchoalveolar lavage fluid (BALF) concentration of activated PC (APC) and the therapeutic effect of the intratracheal administration of APC on BLM-induced lung fibrosis in mice. APC levels in BALF were significantly lower in BLM-treated animals… CONTINUE READING

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