Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.

@article{Aguero2016IntratrachealGD,
  title={Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.},
  author={Jaume Aguero and Kiyotake Ishikawa and Lahouaria Hadri and Carlos Garc{\'i}a Santos-Gallego and Kenneth Michael Fish and Erik Kohlbrenner and Nadjib Hammoudi and Changwon Kho and Ahyoung Lee and Borja Ib{\'a}{\~n}ez and Ana Garc{\'i}a-{\'A}lvarez and Krisztina M Zsebo and Bradley A Maron and Maria Plataki and Valentin Fuster and Jane A. Leopold and Roger J. Hajjar},
  journal={Journal of the American College of Cardiology},
  year={2016},
  volume={67 17},
  pages={
          2032-46
        }
}
BACKGROUND Pulmonary hypertension (PH) is characterized by pulmonary arterial remodeling that results in increased pulmonary vascular resistance, right ventricular (RV) failure, and premature death. Down-regulation of sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) in the pulmonary vasculature leads to perturbations in calcium ion (Ca(2+)) homeostasis and transition of pulmonary artery smooth muscle cells to a proliferative phenotype. OBJECTIVES We assessed the feasibility of sustained… CONTINUE READING