Intrathymic changes in murine CD3, CD5 and CD8 expression after in vivo administration of anti-CD4.

Intrathymic development of murine cortical and medullary thymocyte subpopulations was examined after in vivo administration of anti-CD4 mAb. Four days after mice received 1 mg anti-CD4, expression of CD4 was reduced to about 25% the levels of controls. On cortical CD8+/PNAhigh thymocytes, CD5 and CD8 expression both decreased, but not in parallel, whereas… CONTINUE READING