Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A

@article{Weinmann2006IntrathecallyIA,
  title={Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A},
  author={Oliver Weinmann and Lisa Schnell and Arko Ghosh and Laura Montani and Martin E. Schwab},
  journal={Molecular and Cellular Neuroscience},
  year={2006},
  volume={32},
  pages={161-173}
}
Neutralizing antibodies against the neurite growth inhibitory protein Nogo-A are known to induce regeneration, enhance compensatory growth, and enhance functional recovery. In intact adult rats and monkeys or spinal cord injured adult rats, antibodies reached the entire spinal cord and brain through the CSF circulation from intraventricular or intrathecal infusion sites. In the tissue, anti-Nogo antibodies were found inside Nogo-A expressing oligodendrocytes and neurons. Intracellularly, anti… CONTINUE READING

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