Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat.

@article{Kaneko2000IntrathecallyAG,
  title={Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat.},
  author={M. Kaneko and Caroline Mestre and Emilio S{\'a}nchez and Donna L Hammond},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 2},
  pages={743-51}
}
In the present study, we investigated the effects of intrathecal gabapentin on nociceptive behaviors and the numbers of spinal Fos-like immunoreactive (Fos-LI) neurons evoked by injection of 0.25 to 2.5% formalin in the hindpaw of the rat. Pretreatment with gabapentin dose dependently decreased flinches and weighted pain scores in phase 2, but not phase 1, at each concentration of formalin. The highest dose of gabapentin (100 microgram) shifted the EC(50) values of formalin for both flinches… CONTINUE READING

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