Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer pain.

  title={Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer pain.},
  author={Dorothy Brown and Kimberly A Agnello and Michael J Iadarola},
  volume={156 6},
Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. Prolonged calcium influx induced by RTX causes cytotoxicity and death of only those sensory neurons that express the TRPV1 ion channel leading to selective targeting and permanent deletion of the… CONTINUE READING
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