Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone

@article{Hughes2015IntrathecalRS,
  title={Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone},
  author={Sam W Hughes and Louise Hickey and Lucy F Donaldson and Bridget M Lumb and Anthony E. Pickering},
  journal={PAIN},
  year={2015},
  volume={156},
  pages={328–334}
}
Abstract The descending noradrenergic (NAergic) projection to the spinal cord forms part of an endogenous analgesic system. After nerve injury, a localised failure in this compensatory system has been implicated as a permissive factor in the development of neuropathic sensitisation. We investigated whether restoring descending NAergic tone with intrathecal reboxetine can oppose the development of the neuropathic pain phenotype after tibial nerve transection (TNT). Rats had a lumbar intrathecal… Expand
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