Intrathecal pethidine: pharmacology and clinical applications.

  title={Intrathecal pethidine: pharmacology and clinical applications.},
  author={Warwick D Ngan Kee},
  journal={Anaesthesia and intensive care},
  volume={26 2},
Pethidine is the only member of the opioid family that has clinically important local anaesthetic activity in the dose range normally used for analgesia. Pethidine is unique as the only opioid in current use that is effective as the sole agent for spinal anaesthesia. In lower doses, intrathecal pethidine is also an effective analgesic for treating pain in labour. This paper reviews the pharmacology of intrathecal pethidine and clinical experience reported to date. Articles reviewed include… CONTINUE READING
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