Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.

@article{Shahid2011IntrathecalOA,
  title={Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.},
  author={Israt Z Shahid and Ahmed K Abdel Rahman and Paul M. Pilowsky},
  journal={British journal of pharmacology},
  year={2011},
  volume={162 4},
  pages={961-73}
}
BACKGROUND Intrathecal (i.t.) injection of orexin A (OX-A) increases blood pressure and heart rate (HR), but the effects of OX-A on sympathetic and phrenic, nerve activity, and the baroreflex(es), somato-sympathetic and hypoxic chemoreflex(es) are unknown. EXPERIMENTAL APPROACH Urethane-anaesthetized, vagotomized and artificially ventilated male Sprague-Dawley rats were examined in this study. The effects of i.t. OX-A (20 nmol 10 µL⁻¹) on cardiorespiratory parameters, and responses to… CONTINUE READING

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Intrathecal orexin A increases sympathetic outflow and respiratory drive and modulates physiological reflexes

  • IZ Shahid, PM Pilowsky
  • Proceedings of the Australian Neuroscience…
  • 2010
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