Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain.

@article{Cahill2003IntrathecalNG,
  title={Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain.},
  author={Catherine M Cahill and Andy Dray and Terence J. Coderre},
  journal={Neuropharmacology},
  year={2003},
  volume={45 4},
  pages={543-52}
}
It is without dispute that the treatment of neuropathic pain is an area of largely unmet medical need. Available analgesics, such as morphine, either have minimal effects in neuropathic pain patients, or are not always well tolerated due to concurrent adverse effects. The chronicity of neuropathic pain is thought to be related to many neurochemical changes in the dorsal root ganglia (DRG) and spinal cord, including a reduction in the retrograde transport of nerve growth factor (NGF). In this… CONTINUE READING
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