Intrathecal methysergide antagonizes antinociception produced by subdiaphragmatic vagal stimulation

@article{Thurston1990IntrathecalMA,
  title={Intrathecal methysergide antagonizes antinociception produced by subdiaphragmatic vagal stimulation},
  author={Cindy L. Thurston and Alan Randich},
  journal={Pain},
  year={1990},
  volume={41}
}
AIM OF INVESTIGATION: The involvement of the endogenous opioid system in the control of tonic pain is still debated. In the present study a possible role of the central beta-endorphin (B-EP) system in the modulation of animal behaviour during acute prolonged pain was investigated in unanaesthetized, freely-moving rats. m: Male Sprague-Dawley rats weighing 300-350 g were icv injected with 6.5 pl of anti-B-EP or normal rabbit serum (n=5 per group). Six hours later a small amount of dilute… CONTINUE READING
BETA