Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats
@article{Lin2011IntrathecalLA, title={Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats}, author={Ying-Chao Lin and Shi-Ying Huang and Yen-Hsuan Jean and Wu-Fu Chen and C. Sung and Erl-Shyh Kao and H. Wang and C. Chakraborty and C. Duh and Zhi-Hong Wen}, journal={Behavioural Pharmacology}, year={2011}, volume={22}, pages={739–750} }
The investigators previously found that the administration of lemnalol, a natural marine compound isolated from the Formosan soft coral Lemnalia cervicorni, produced anti-inflammatory and analgesic effects in carrageenan-injected rats. Recently, several studies have demonstrated that the development and maintenance of neuropathic pain are accompanied by releasing of proinflammatory mediators from activated glial cells in the spinal cord. In this study, we investigated the antinociceptive… CONTINUE READING
Topics from this paper
22 Citations
Flexibilide Obtained from Cultured Soft Coral Has Anti-Neuroinflammatory and Analgesic Effects through the Upregulation of Spinal Transforming Growth Factor-β1 in Neuropathic Rats
- Medicine
- Marine drugs
- 2014
- 27
- PDF
Sinularin from Indigenous Soft Coral Attenuates Nociceptive Responses and Spinal Neuroinflammation in Carrageenan-Induced Inflammatory Rat Model
- Medicine
- Marine drugs
- 2012
- 46
- PDF
Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression
- Medicine
- Marine drugs
- 2013
- 19
- PDF
Anti-Inflammatory and Analgesic Effects of the Marine-Derived Compound Comaparvin Isolated from the Crinoid Comanthus bennetti
- Biology, Medicine
- Molecules
- 2014
- 21
- PDF
Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats
- Medicine
- Evidence-based complementary and alternative medicine : eCAM
- 2016
- 28
- PDF
TGF-β1 attenuates spinal neuroinflammation and the excitatory amino acid system in rats with neuropathic pain.
- Medicine
- The journal of pain : official journal of the American Pain Society
- 2013
- 33
Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats
- Medicine
- The Journal of Headache and Pain
- 2016
- 14
Chemical Constituents of Cultured Soft Coral Sinularia flexibilis
- Chemistry
- Chemistry of Natural Compounds
- 2018
- 3
IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines
- Biology, Medicine
- Molecular medicine reports
- 2017
- 25
- PDF
Venom-based biotoxins as potential analgesics
- Medicine
- Expert review of neurotherapeutics
- 2014
- 17
- Highly Influenced
References
SHOWING 1-10 OF 76 REFERENCES
Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury
- Medicine
- Brain, Behavior, and Immunity
- 2007
- 122
Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni.
- Chemistry, Medicine
- European journal of pharmacology
- 2008
- 104
- PDF
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
- Medicine
- Pain
- 2005
- 600
- Highly Influential
Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.
- Medicine
- The Journal of pharmacology and experimental therapeutics
- 2001
- 268
- PDF
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
- Medicine
- European journal of pharmacology
- 2008
- 123
Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy
- Medicine
- Journal of Pharmacology and Experimental Therapeutics
- 2003
- 692
- PDF
Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat.
- Medicine
- European journal of pharmacology
- 2007
- 49
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain.
- Medicine
- European journal of pharmacology
- 2007
- 204
Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury‐induced neuropathic pain in rats
- Biology, Medicine
- British journal of pharmacology
- 2009
- 98
- PDF