Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.

@article{Verberne1990IntrathecalKR,
  title={Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.},
  author={Anthony J M Verberne and Robert E. Widdop and C. Maccarrone and Bevyn Jarrott and Philip M. Beart and William J. Louis},
  journal={Neuroscience letters},
  year={1990},
  volume={114 3},
  pages={309-15}
}
In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs… CONTINUE READING

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