Intrathecal glycine for pain and dystonia in complex regional pain syndrome

@article{Munts2009IntrathecalGF,
  title={Intrathecal glycine for pain and dystonia in complex regional pain syndrome},
  author={Alexander G. Munts and Anton A. van der Plas and Joan H. C. Voormolen and Johan Marinus and Irene M. Teepe-Twiss and Willem Onkenhout and Joop M. A. van Gerven and Jacobus J. van Hilten},
  journal={PAIN},
  year={2009},
  volume={146},
  pages={199-204}
}

Tables from this paper

Reflex Mechanisms in CRPS-Related Dystonia

A computational neuromuscular model has been developed and methods have been developed to quantify proprioceptive reflexes in vivo during postural control of patients with fixed dystonia to gain insight into the pathophysiology of fixed dySTONia and develop a diagnostic protocol.

An explanatory study evaluating the muscle relaxant effects of intramuscular magnesium sulphate for dystonia in complex regional pain syndrome.

Complex Regional Pain Syndrome: State of the Art Update

Although the pathophysiology of complex regional pain syndrome (CRPS) is not fully understood, recent work suggests that bisphosphonates may be useful in CRPS management and that the N-methyl-d-aspartate receptor antagonist ketamine significantly reduces CRPS pain when administered topically or intravenously at subanesthetic dosages.

Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy.

The findings lend support to the role of GABA (gamma aminobutyric acid)-ergic mechanisms in this cause of dystonia and stimulate new directions of research on this topic.

Intramuscular botulinum toxin A (BtxA) in complex regional pain syndrome.

Intramuscular injection of botulinum toxin A in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS in this retrospective case series.

Fixed Dystonia in Complex Regional Pain Syndrome: a Descriptive and Computational Modeling Approach

Findings derived from a neuromuscular model suggest that aberrant force feedback regulation from Golgi tendon organs involving an inhibitory interneuron may underpin the typical fixed flexion postures in CRPS patients with dystonia.

Intramuscular botulinum toxin in complex regional pain syndrome: case series and literature review.

Intramuscular injection of botulinum toxin in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS.

Impaired Inhibitory Force Feedback in Fixed Dystonia

It is concluded that aberrant force feedback plays a role in fixed dystonia, for both CRPS and non-CRPS patients.

Treatment of complex regional pain syndrome: an updated systematic review and narrative synthesis

An updated review of the evidence pertaining to the treatment of CRPS derived from recent randomized-controlled trials (RCTs) found that published trials continue to support the use of bisphosphonates and short courses of oral steroids in the setting ofCRPS.

References

SHOWING 1-10 OF 72 REFERENCES

Intrathecal baclofen for dystonia of complex regional pain syndrome

Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy.

Six women who had reflex sympathetic dystrophy with multifocal or generalized tonic dystonia received bolus injections of 50 and 75 microg of baclofen, and in one woman, the pain and violent jerks disappeared and the dystonic posturing of the arm decreased.

Memantine Treatment of Complex Regional Pain Syndrome: A Preliminary Report of Six Cases

The use of Memantine for treatment of CRPS seems promising and supports the hypothesis of a CNS contribution to the pathogenesis and maintenance of neuropathic pain syndromes.

Analgesic Effects of Ketamine Ointment in Patients With Complex Regional Pain Syndrome Type 1

Topical application of KET appears to be beneficial for the patients with acute early dystrophic stage of CRPS I because of either its local anesthetic effect or NMDA receptor antagonist action.

The important role of neuropeptides in complex regional pain syndrome

Increased systemic CGRP levels in patients with acute CRPS suggest neurogenic inflammation as a pathophysiologic mechanism contributing to vasodilation, edema, and increased sweating, however, pain and hyperalgesia, in particular in chronic stages, were independent of increased neuropeptide concentration.

Intrathecal Baclofen: A Useful Agent in the Treatment of Well-Established Complex Regional Pain Syndrome

IT baclofen appears to be an option for patients with intractable CRPS who have failed other modalities, including IT morphine.

Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand

A bilateral disinhibition of the motor cortex in patients with complex regional pain syndrome is shown, showing a significant reduction of intracortical inhibition on both sides of patients with CRPS compared with control subjects.

The motor system shows adaptive changes in complex regional pain syndrome.

The results of this study suggest that substantial adaptive changes within the central nervous system may contribute to motor symptoms in CRPS.
...