Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors.

@article{MarichalCancino2012IntrathecalDI,
  title={Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors.},
  author={Bruno A Marichal-Cancino and Abimael Gonz{\'a}lez-Hern{\'a}ndez and Guadalupe Manrique-Maldonado and Inna Ruiz-Salinas and Alain H Altamirano-Espinoza and Antoinette MaassenVanDenBrink and Carlos M Villal{\'o}n},
  journal={European journal of pharmacology},
  year={2012},
  volume={692 1-3},
  pages={
          69-77
        }
}
  • Bruno A Marichal-Cancino, Abimael González-Hernández, +4 authors Carlos M Villalón
  • Published 2012
  • Medicine, Chemistry
  • European journal of pharmacology
  • It has been suggested that during a migraine attack trigeminal nerves release calcitonin gene-related peptide (CGRP), producing central nociception and vasodilatation of cranial arteries, including the extracranial branches of the external carotid artery. Since trigeminal inhibition may prevent this vasodilatation, the present study has investigated the effects of intrathecal dihydroergotamine on the external carotid vasodilatation to capsaicin, α-CGRP and acetylcholine. Anaesthetized… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-6 OF 6 CITATIONS

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 50 REFERENCES