Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model.

@article{Ishigaki2007IntrathecalDO,
  title={Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model.},
  author={Aya Ishigaki and Masashi Aoki and Makiko Nagai and Hitoshi Warita and Shinsuke Kato and Masako Kato and Toshikazu Nakamura and Hiroshi Funakoshi and Y. Itoyama},
  journal={Journal of neuropathology and experimental neurology},
  year={2007},
  volume={66 11},
  pages={1037-44}
}
Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. We showed that introduction of the HGF gene into neurons of G93A transgenic mice attenuates motor neuron degeneration and increases the lifespan of these mice. Currently, treatment regimens using recombinant protein are closer to clinical application than gene therapy. To examine its protective effect on motor neurons and therapeutic potential we administered human recombinant HGF (hrHGF) by… CONTINUE READING