Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes.

@article{Furlan2001IntrathecalDO,
  title={Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes.},
  author={Roberto Furlan and Elena Marta Brambilla and Francesca Ruffini and P L Poliani and Alessandra Bergami and P C Marconi and Diego Franciotta and Giuseppe Penna and Giancarlo Comi and L. Adorini and Gianvito Martino},
  journal={Journal of immunology},
  year={2001},
  volume={167 3},
  pages={1821-9}
}
The exclusive detrimental role of proinflammatory cytokines in demyelinating diseases of the CNS, such as multiple sclerosis, is controversial. Here we show that the intrathecal delivery of an HSV-1-derived vector engineered with the mouse IFN-gamma gene leads to persistent (up to 4 wk) CNS production of IFN-gamma and inhibits the course of a chronic-progressive form of experimental autoimmune encephalomyelitis (EAE) induced in C57BL/6 mice by myelin oligodendrocyte glycoprotein (MOG)(35-55… CONTINUE READING
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