Intrathecal beta-funaltrexamine antagonizes intracerebroventricular beta-endorphin- but not morphine-induced analgesia in mice.

@article{Suh1988IntrathecalBA,
  title={Intrathecal beta-funaltrexamine antagonizes intracerebroventricular beta-endorphin- but not morphine-induced analgesia in mice.},
  author={Harold Hongwon Suh and Leon Fu Tseng},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={245 2},
  pages={587-93}
}
We have reported previously that beta-endorphin and morphine administered supraspinally produce analgesia by activating different descending pain inhibitory systems in rats. The descending system activated by beta-endorphin involves a spinal endorphinergic system whereas the descending system activated by morphine does not. To determine if this differential action of intraventricular beta-endorphin and morphine also occurs in mice, the effects of pretreatment with intrathecal (i.t.) and i.c.v… CONTINUE READING