Intrathecal baclofen for spasticity of spinal origin: seven years of experience.

@article{Penn1992IntrathecalBF,
  title={Intrathecal baclofen for spasticity of spinal origin: seven years of experience.},
  author={Richard D. Penn},
  journal={Journal of neurosurgery},
  year={1992},
  volume={77 2},
  pages={
          236-40
        }
}
  • R. Penn
  • Published 1 August 1992
  • Medicine
  • Journal of neurosurgery
A total of 66 consecutive patients with severe spasticity of spinal cord origin were screened with intrathecal baclofen, and all but two responded with a two-point decrease in their Ashworth spasticity scale and/or spasm scale score. Of these, 62 elected to receive chronic intrathecal baclofen administration by means of an implanted delivery system. These patients have been followed for an average of 30 months (the first three for 81 months). Intrathecal baclofen has been well tolerated and all… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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271 Citations

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Intrathecal baclofen for treatment of intractable spinal spasticity.
Intrathecal Baclofen Dosage for Long-Term Treatment of Patients With Spasticity Due to Traumatic Spinal Cord Injuries or Multiple Sclerosis
TLDR
The increased dosage in MS patients compared with patients diagnosed with SCI probably reflects the progressive disease course and suggests possible pump failure, triggering factors for spasticity or progressive spinal disease.
Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity.
TLDR
It is concluded that intrathecal baclofen delivered by an implanted programmable pump is a safe, effective, and cost-efficient method for treatment of severe intractable spinal spasticity.
Intrathecal baclofen administration for control of severe spinal spasticity: functional improvement and long-term follow-up.
Functional Outcome and Clinical Significance of Long-term Intrathecal Baclofen Therapy for Severe Spasticity
TLDR
Over the time span studied, muscle tone and spontaneous painful muscle spasms were markedly reduced and remained stable at two steps lower than prior to treatment when assessed by the Ashworth spasticity and clinical spasms scale.
Management of severe spasticity with intrathecal baclofen delivered by a manually operated pump.
TLDR
It is concluded that intrathecal baclofen, delivered by a manually operated implanted pump, is an effective treatment for severe spasticity in most patients.
Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients
TLDR
Complications were frequent, involving mainly the catheters, which would require further technical improvements, Nevertheless, ITB remained effective in the long term and patients were satisfied.
Management of spasticity in multiple sclerosis by intrathecal baclofen.
TLDR
Since its introduction, chronic intrathecal baclofen infusion has been proved to improve spasticity, spasms and related pain and is carried out by the Asworth Scale although there is not yet general accordance on the validity of this scale.
Intrathecal baclofen after traumatic brain injury: early treatment using a new technique to prevent spasticity.
TLDR
Continuous administration of baclofen via the intrathecal route using this new technique seems to reduce autonomic disorders and spasticity during the early course of severe traumatic head injury.
Intrathecal baclofen in the treatment of spasticity.
TLDR
Intrathecal baclofen is currently the most effective means of treating diffuse abnormal spasticity of both cerebral and spinal origin in the adult and pediatric patient.
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References

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TLDR
Seven patients with spasticity of spinal cord origin have been maintained for up to 2 years with continuous spinal intrathecal infusion of baclofen, with the greatest benefits to the patients improvement in activities of daily living and better sleep due to reduced spasms.
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TLDR
In most cases, spasticity, performance of bowel and bladder programs, and performance of ADL improved after delivery of intrathecal baclofen, and this appears to be due to the decrease in hypertonicity and the increased ease of movement in affected extremities.
Intrathecal Baclofen for Severe Spasticity
  • R. Penn
  • Medicine
    Annals of the New York Academy of Sciences
  • 1988
TLDR
The clinical studies on sixteen patients on chronic intrathecal baclofen are presented and the reasons why the technique seems to work so well are discussed, and what lessons can be drawn for other neurological applications of drug pumps are discussed.
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TLDR
Twenty eight patients with severe, intractable spasticity have been treated by chronic intrathecal administration of baclofen with implantable programmable drug-administration-device (DAD) with therapeutic effect documented.
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TLDR
It is suggested that intrathecal baclofen is an effective long-term treatment for spinal spasticity that has not responded to oral bacl ofen.
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TLDR
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TLDR
It is concluded that continuous administration of intrathecal baclofen is an effective and safe modality for spasticity control in patients who are refractory to oral medications.
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TLDR
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TLDR
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