Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.

@article{Ochs1989IntrathecalBF,
  title={Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.},
  author={G{\"u}nter Ochs and Albrecht Struppler and B. A. Meyerson and Bengt Linderoth and Jan M. Gybels and Brian P. Gardner and P. J. Teddy and Ali Jamous and P Weinmann},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={1989},
  volume={52},
  pages={933 - 939}
}
Twenty eight patients with severe, intractable spasticity have been treated by chronic intrathecal administration of baclofen. An implantable programmable drug-administration-device (DAD) was used with a permanent intrathecal catheter. Infusion of 50 to 800 micrograms/day of baclofen completely abolished spasticity. Follow-up was up to two years. Therapeutic effect was documented by clinical assessment of tone, spasms and reflexes and by electrophysiological recordings of mono- and polysynaptic… 

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  • 1997
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The mechanism of action of baclofen, the delivery systems available and the criteria for patient selection are described, and the screening phase, surgical procedure and specific postoperative observations are described.

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Despite an advanced stage of the disease at the time of pump placement, the complication rate was low, the efficacy of this treatment was maintained over time, and in almost all cases, IT baclofen was proposed to patients who were no longer able to walk.

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  • R. Penn
  • Medicine
    Journal of neurosurgery
  • 1992
TLDR
It is suggested that long-term control of spinal spasticity by intrathecal baclofen can be achieved in most patients.

Intrathecal baclofen for treatment of intractable spinal spasticity.

Intrathecal baclofen infusion: an innovative approach for controlling spinal spasticity.

  • S. SavoyJ. Gianino
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    Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
  • 1993
TLDR
An innovative therapy for controlling spasticity is introduced and the nurse's role in patient selection and management is discussed.

Intrathecal baclofen for treatment of spasticity.

TLDR
The paper by Ochs et al' confirms the findings of Dr Penn et al 23 that chronic intrathecal administration of baclofen may be effective in relieving spasticity due to spinal cord damage and confirms that the response of intratheCal bacl ofen will vary according to the underlying pathological process.

Intrathecal baclofen in hereditary spastic paraparesis.

Intrathecal baclofen has not been previously evaluated for the treatment of the disabling hypertonia associated with hereditary spastic paraparesis. Muscle tone and deep-tendon reflexes were

Long Term Intrathecal Baclofen Therapy in Patients with Intractable Spasticity

TLDR
Intrathecal baclofen therapy delivered by means of implanted infusion pumps was used for nine patients with severe spasticity who showed improvement in many areas, including ability to transfer, seating, pain control, personal care, and liability to skin breakdown.

Intrathecal Baclofen for Intractable Spinal Spasticity – a Double-blind Cross-over Comparison with Placebo in 6 Patients

TLDR
In contrast to the placebo injections, the group responded to the baclofen injections with subjective and objective, clinically significant improvement in parameters of spasticity in their lower limbs, including muscle tone, frequency of spasms, hyperreflexia and passive range of joint motion.
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