Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.

@article{Roh2008IntrathecalAO,
  title={Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.},
  author={D H Roh and Hyun-Woo Kim and S Y Yoon and H Seo and Young-Bae Kwon and Kee-Won Kim and H Han and Alvin James Beitz and Jang-Hern Lee},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 16},
  pages={3644-54}
}
Sigma sites, originally proposed as opioid receptor subtypes, are currently thought to represent unique receptors with a specific pattern of drug selectivity, a well-established anatomical distribution and broad range of functional roles including potential involvement in nociceptive mechanisms. We have recently demonstrated that intrathecal (i.t.) treatment with a sigma-1 receptor antagonist reduced formalin-induced pain behavior. In the present study, we investigated the potential role of… CONTINUE READING

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