Intrathecal Therapeutics: Device Design, Access Methods, and Complication Mitigation

@article{Nagel2018IntrathecalTD,
  title={Intrathecal Therapeutics: Device Design, Access Methods, and Complication Mitigation},
  author={S. Nagel and C. Reddy and L. Frizon and M. Holland and A. Machado and G. T. Gillies and M. Howard},
  journal={Neuromodulation: Technology at the Neural Interface},
  year={2018},
  volume={21}
}
The intrathecal space remains underutilized for diagnostic testing, invasive monitoring or as a pipeline for the delivery of neurological therapeutic agents and devices. The latter including drug infusions, implants for electrical modulation, and a means for maintaining the physiologic pressure column. The reasons for this are many but include unfamiliarity with the central nervous system and the historical risks that continue to overshadow the low complication rates in modern clinical series. 
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