Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain

@article{Cirillo2009IntrathecalNA,
  title={Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain},
  author={Giovanni Cirillo and Carlo Cavaliere and Maria Rosaria Bianco and Antonietta De Simone and Anna Maria Colangelo and Stefania Sellitti and Lilia Alberghina and Michele Papa},
  journal={Cellular and Molecular Neurobiology},
  year={2009},
  volume={30},
  pages={51-62}
}
Nerve growth factor (NGF), an essential peptide for sensory neurons, seems to have opposite effects when administered peripherally or directly to the central nervous system. We investigated the effects of 7-days intrathecal (i.t.) infusion of NGF on neuronal and glial spinal markers relevant to neuropathic behavior induced by chronic constriction injury (CCI) of the sciatic nerve. Allodynic and hyperalgesic behaviors were investigated by Von Frey and thermal Plantar tests, respectively. NGF… CONTINUE READING
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