Intrathecal Leucovorin After Intrathecal Methotrexate Overdose

@article{Jardine1996IntrathecalLA,
  title={Intrathecal Leucovorin After Intrathecal Methotrexate Overdose},
  author={Lisa Jardine and Liam Ingram and Werner A. Bleyer},
  journal={Journal of Pediatric Hematology/Oncology},
  year={1996},
  volume={18},
  pages={302–304}
}
Purpose: Intrathecal methotrexate is a standard and important therapy in acute leukemia. Unfortunately, overdose is a well reported complication of this therapy. We report a fatal event secondary to intrathecal leucovorin. Patients, Methods, and Results: An 11-year-old boy with a 6-month history of treatment of acute lymphocytic leukemia received an “overdose” of 20 mg of intrathecal methotrexate. He was treated with intrathecal leucovorin and subsequently experienced severe neurotoxicity and… 
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TLDR
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TLDR
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TLDR
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